Diethyl Ether → Ethyl 4-[hydroxy(phenyl)amino]-4-oxobutanoate

Participants

Reaction Steps

To a stirred solution of N-phenylhydroxylamine (8 g) in ether (80 ml) at 0° C. was added dropwise over 10 minutes ethyl succinyl chloride (5.76 g). The reaction mixture was allowed to attain room temperature overnight, filtered and the filtrate evaporated to give N-(3-ethoxycarbonylpropionyl)-N-phenylhydroxylamine as an oil.

Provenance & Evidence