HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 6-Chloronicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Oxo-1lambda~5~-pyridine-2,5-dicarboxylic acid | HCID 13643503 | — |
| Reactant | HCID 178418479 | HCID 178418479 | — |
| Product | 6-Chloronicotinic acid | HCID 79222 | 53.8% |
Reaction Steps
This example proceeded as in Example 1, but the reaction was carried out at 0° to 5° C. the bath used had 25.5 g of Ac2O, 20 g of Et3N, 350 g of CH2Cl2 and 18.3 of isocinchomeronic acid-N-oxide. The yield was 53.8 percent of 6-chloronicotinic acid (2-chloro-5-pyridine carboxylic acid), and 39.0 percent of 6-hydroxynicotinic acid (2-hydroxy-5-pyridine-carboxylic acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04556716 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-ea5c558f9afc490ca49205146ded2cd9 |
| Source note | uspto-grants-1985_12 |