HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 6-Chloronicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1-Oxo-1lambda~5~-pyridine-2,5-dicarboxylic acid | HCID 13643503 | — |
| Reactant | HCID 178418479 | HCID 178418479 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 6-Chloronicotinic acid | HCID 79222 | 40.8% |
Reaction Steps
A sludge of 50 g of CH2Cl2, 10 g of Et3N and 9.1 g of isocinchomeronic acid-N-oxide was placed in an autoclave. Under 4.5 atu. and at 65° C., a mixture of 10.2 g of Ac2O, 5 g of Et3N and 50 g of CH2Cl2 was additionally pumped in. At the end of the addition, the reaction mixture was processed as in Example 1. The yield was 40.8 percent of 2-chloro-5-pyridine carboxylic acid (6-chloronicotinic acid) and 44.2 percent of 2-hydroxy-5-pyridine carboxylic acid (6-hydroxynicotinic acid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04556716 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-492d721a0e764f458c2d4d734facc14e |
| Source note | uspto-grants-1985_12 |