Methyl iodide → HCID 20257055, compound

HRID 637542Notes

Reaction equation

HRID 637542 reaction equation
[CH3:1][I:2].[CH3:3][S:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH:16]([OH:25])[CH2:17][O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][CH:9]=1>C(#N)C>[I-:2].[OH:25][CH:16]([CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([O:7][CH2:6][CH2:5][S+:4]([CH3:1])[CH3:3])=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20257059HCID 20257059, compound

Product 1

HCID 20257055HCID 20257055, compoundYield 93.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A 5 g quantity of methyl iodide was added to 3.34 g of 2-{4-(2-hydroxy-3-phenoxypropoxy)phenoxy}ethyl methyl sulfide and 5 ml of acetonitrile. The mixture was stirred at room temperature for 24 hours. The reaction mixture was concentrated and the residue was recrystallized from ethanol-ether, giving 4.45 g of 2-{4-(2-hydroxy-3-phenoxypropoxy)phenoxy}ethyldimethylsulfonium iodide in 93.5% yield, M.P. 112° to 112.8° C.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-98009f344cdf44599b047777cd435a89
Source dataset
uspto-grants-1985_12
Patent number
US04556737

Reaction notes

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