反应详情

温度

90 °C

In 300 ml of dimethyl sulfoxide was dissolved 35 g of sodium cyanide by heating at 90° C., and 45 g of 2-fluoro-α-methylbenzyl chloride was added. The mixture was stirred at 90° C. for 4 hours, and then cooled. Ice-water was added and the mixture was extracted with n-hexane. The n-hexane layer was washed with water and dried over anhydrous magnesium sulfate and the solvent was evaporated off. The residue obtained was purified by distillation under reduced pressure to afford 36 g of 2-fluoro-α-methylbenzyl cyanide, b.p.0.5 55° C.

1. temperaturecooled
2. extractionthe mixture was extracted with n-hexane
3. washThe n-hexane layer was washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. customthe solvent was evaporated off
6. customThe residue obtained
7. distillationwas purified by distillation under reduced pressure