HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyrimidine → HCID 13421427, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyrimidine | HCID 7978 | — |
| Reactant | 2-[1-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-oxoethoxy]-3-hydroxypropanal | HCID 247466 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13421427 | HCID 13421427 | 99.7% |
Reaction Steps
[R-(R*, R*)]-α-(1-Formyl-2-hydroxyethoxy)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidineacetaldehyde, (uridinedialdehyde), (6.05 g) was dissolved in water (25 ml). To the solution was added 2-aminopyrimidine (2.38 g). The mixture was stirred at ambient temperature for eight hours to give a clear solution. The solution was lyophilized to give white powder of 1-[(2R, 6R)-3,5-dihydroxy-6-hydroxymethyl-4-(2-pyrimidinyl)morpholin-2-yl]uracil (8.40 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04558047 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-07c01c9157384e64b73ae46f292cc4d2 |
| Source note | uspto-grants-1985_12 |