反应详情

200 mg of platinum oxide are added to a solution of 1.42 g (5.60 mmole) of 5-chloro-3-hydroxy-6-(piperidin-1-yl)-2,3-dihydrobenzofuran in 20 ml of ethanol and the whole is hydrogenated at 3 atmospheres. The catalyst is filtered off and the filtrate is concentrated in a vacuum rotary evaporator. The residue is chromatographed over silica gel using methylene chloride as eluant. Recrystallisation from petroleum ether yields 5-chloro-6-(piperidin-1-yl)-2,3-dihydrobenzofuran having a melting point of 38°-40°.

1. filtrationThe catalyst is filtered off
2. concentrationthe filtrate is concentrated in a vacuum rotary evaporator
3. customThe residue is chromatographed over silica gel
4. customRecrystallisation from petroleum ether