Hydrochloric Acid → HCID 20255631, compound

Participants

Reaction Steps

5 ml of 6N hydrochloric acid are added to a mixture of 7.5 g (46.5 mmole) of 6-amino-3,5-dimethylbenzofuran, 7.5 ml (58 mmole) of 2,5-dimethoxytetrahyrofuran and 150 ml of dioxane and the whole is boiled under reflux for 40 minutes. The whole is concentrated by evaporation in vacuo and the residue is taken up in methylene chloride and washed three times with water. The crude product obtained after drying and concentration by evaporation of the organic phase is chromatographed over silica gel with petroleum ether/ether. Subsequent distillation of the pure fractions in a bulb tube (120°/4.10-2 torr) yields 3,5-dimethyl-6-(pyrrol-1-yl)-benzofuran having a melting point of 43°-45°.

Provenance & Evidence