HCID 20255631, compound → HCID 20255662, compound

Participants

Reaction Steps

A mixture of 8 g (37.9 mmole) of 3,5-dimethyl-6-(pyrrol-1-yl)-benzofuran, 1.6 g of 5% palladium on carbon and 80 ml of dioxane is hydrogenated at 35° and a pressure of 4 bar. To complete the reaction, 0.8 g, each time, of 5% palladium on carbon is added a further three times during hydrogenation. After a total of 100 hours, the catalyst is filtered off and the filtrate is concentrated by evaporation in vacuo. Chromatography of the residue over silica gel (petroleum ether/methylene chloride) and distillation of the pure fractions in a bulb tube (120°/2.10-2 torr) yields 3,5-dimethyl-6-(pyrrol-1-yl)-2,3-dihydrobenzofuran in the form of a colourless oil.

Provenance & Evidence