1-(4-Fluorophenyl)piperazine → HCID 13343503, compound

Participants

Reaction Steps

0.025 mol (4.5 g) of 1-(4-fluorophenyl)-piperazine and 0.02 mol (5.12 g) of 3-methyl-6-(2-bromoethyl)-benzoxazolinone, dissolved beforehand in 50 cm3 of dioxane, were introduced into a 100 cm3 flask with a ground glass neck, fitted with a reflux condenser, and the mixture was then heated under reflux for 72 hours, with stirring. After cooling, filtration and drying, 100 cm3 of a 3% strength aqueous solution of sodium hydroxide were added to the precipitate obtained, and the mixture was stirred for 30 minutes. Filtration, drying and recrystallisation from toluene gave 4.6 g of the title product having a melting point of 161°-164° C.

Provenance & Evidence