化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 5-Thiazolecarboxamide, 2-(4-methoxyphenyl)-4-methyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Ethyl 2-chloroacetoacetate | HCID 11858 | — |
| 反応物 | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| 反応物 | 4-Methoxybenzamide | HCID 76959 | — |
| 反応物 | Ethyl 2-(4-methoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate | HCID 7540952 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Thiazolecarboxamide, 2-(4-methoxyphenyl)-4-methyl- | HCID 3068075 | 69% |
反応手順
Into a mixed solvent of 50 ml of aqueous 28% ammonia and 450 ml of ethanol, 13.9 g of ethyl 2-(4-methoxyphenyl)-4-methylthiazole-5-carboxylate which had been prepared by heating a mixture of p-methoxybenzamide, ethyl α-chloroacetoacetate, phosphorus pentasulfide and n-butyl alcohol under a reflux for 5 hours was dissolved. Then, in a similar manner as in Example 3 the object was obtained as colourless aciculate melting at 179.5° to 180.5° C. in an amount of 8.6 g corresponding to the yield of 69%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04558059 |
| 出典データセット | uspto-grants-1985_12 |
| ORD ID | ord-09f717849cbc469691ad175eb4290b29 |
| 出典メモ | uspto-grants-1985_12 |