Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aluminum Stearate | HCID 12496 | — |
| Reactant | Apraclonidine dihydrochloride | HCID 21479682 | — |
| Product | Apraclonidine | HCID 2216 | — |
Reaction Steps
The aluminum stearate was dispersed with stirring in a portion of the sunflower oil heated to 115° C. The dispersion was added to the rest of the sunflower oil heated to 140° C. The gel was stirred at 130° C. for 15 minutes and then allowed to cool without stirring to room temperature. The milled p-Amino Clonidine dihydrochloride was dispersed in the cooled gel base and then passed through a colloid mill to produce a fine, homogenous dispersion. The dispersion was filled into plastic bottles fitted with a dosing pump.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04558063 |
|---|
| Source dataset | uspto-grants-1985_12 |
|---|
| ORD ID | ord-c167cef229d340d2aba763d3cc9a83b8 |
|---|
| Source note | uspto-grants-1985_12 |
|---|
