反应详情

1.75 g of 2,3-dichlorobenzaldehyde, 2.2 g of 3-acetonyl-1,2,4-oxadiazole, 1.6 g of sec.-butyl acetoacetate and 1.2 g of 25% strength aqueous ammonia solution in 50 ml of ethanol are heating to boiling for 6 hours. After concentrating, there remains an oily residue which is triturated with ether/petroleum ether and gradually crystallises. The resulting solid is then recrystallised from ethyl acetate/isopropanol: melting point=116° to 117° C.

1. concentrationAfter concentrating
2. customis triturated with ether/petroleum ether
3. customgradually crystallises
4. customThe resulting solid is then recrystallised from ethyl acetate/isopropanol