HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 12783825, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-Aminopentan-1-ol | HCID 75634 | — |
| Reactant | 3-Pyridylmethyl-2-methylthio-4-pyrimidone | HCID 12783823 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 12783825 | HCID 12783825 | — |
Reaction Steps
2-Methylthio-5-(3-pyridylmethyl)-4-pyrimidone (23.3 g) and 5-aminopentanol (24.5 g) were fused together at 170°-180° for 2 hours. Water was added to the cooled residue and the mixture was adjusted to pH7 with dilute hydrochloric acid. The solid (23.8 g) which crystallised out was recrystallised from 2-propanol containing hydrogen chloride to give 2-(5-hydroxypentylamino)-5-(3-pyridylmethyl)-4-pyrimidone dihydrochloride, m.p. 203°-205°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04558128 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-88cb9c0e7fd94c87b90785ac947e5a68 |
| Source note | uspto-grants-1985_12 |