HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 57631607, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-Amino-1-(1-methyl-2-oxo-2-phenyl-ethyl)-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 57632219 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 57631607 | HCID 57631607 | 98.1% |
Reaction Steps
Compound 1 (0.7 g, 2.43 mmol) was dissolved in 34 mL EtOH. NaBH4 (0.18 g, 4.87 mmol) was added in one shot. The reaction stirred at room temperature for 0.5 h. The solution was quenched with sat. NH4Cl and extracted with CH2Cl2 (3 times). The organic layer was washed with brine, dried (MgSO4), concentrated to give a fluffy white solid 2 (0.69 g, 98% yield). MS: Calcd.: 289. Found: 290 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447100B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-25f4a38c61934f6d86d20d74f0d7adcd |
| Source note | uspto-grants-2016_09 |