HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 13578745, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Cvt-2738 | HCID 2608606 | — |
| Reactant | 2-Bromo-1-(2,3-dihydro-1,4-benzodioxin-2-yl)ethan-1-ol | HCID 12608590 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 13578745 | HCID 13578745 | 106.6% |
Reaction Steps
1-(1,4-Benzodioxan-2-yl)-2-bromoethanol (formula H) (12 g) prepared according to J. Med. Chem. 13, 169, (1970), is treated with 1-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine (14 g) in 500 ml of ethanol. The remainder of the procedure is described in Example 1 above and 21 g of the 1-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine is obtained from hexane. The dihydrochloride salt has a melting point of 175°-176° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04558129 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-c34caccd6a43461699b79a2f4056893f |
| Source note | uspto-grants-1985_12 |