反应详情

To a mixture of 3 ml of ethanol and 7 ml of 29% aqueous ammonia was added 1.0 g of 4-oxo-4,5,6,7-tetrahydrobenzofuran, and then the mixture was subjected to reaction in a sealed tube at 150° C. for 12 hours. After completing the reaction, the reaction mixture was concentrated. The resulting residue was applied to a column of silica gel and eluted with a mixed solvent of acetone and ethyl acetate to give 950 mg (yield: 96%) of 4-oxo-4,5,6,7-tetrahydroindole being a light yellowish crystal.

1. customthe mixture was subjected to reaction in a sealed tube at 150° C. for 12 hours
2. customthe reaction
3. concentrationthe reaction mixture was concentrated
4. washeluted with a mixed solvent of acetone and ethyl acetate