HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichlorophenol → 5-(3,4-Dichlorophenoxy)-2-ethylthio-4-pyridinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichlorophenol | HCID 7258 | — |
| Reactant | 5-Chloro-2-ethylthio-4-pyridinecarbonitrile | HCID 13560212 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-(3,4-Dichlorophenoxy)-2-ethylthio-4-pyridinecarbonitrile | HCID 13560227 | 36.2% |
Reaction Steps
5-Chloro-2-ethylthio-4-pyridinecarbonitrile (5.4 g) was mixed with 5.4 g of 3,4-dichlorophenol in the presence of 3.7 g of t-BuOK in 30 ml of THF and 30 ml of DMSO. The mixture was heated at boiling temperature for about 70 hours to give 3.2 g (36%) of the desired 5-(3,4-dichlorophenoxy)-2-ethylthio-4-pyridinecarbonitrile, m.p. 79°-81° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04558134 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-09bf00717649461e9d9fb96b8343f6d1 |
| Source note | uspto-grants-1985_12 |