Chloroform → HCID 47000767, compound

HRID 637835Notes

Reaction equation

HRID 637835 reaction equation
[C:1]1([O:7][CH2:8][CH2:9]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:11]([NH2:14])([CH3:13])[CH3:12].C(Cl)(Cl)[Cl:16]>>[ClH:16].[CH3:12][CH:11]([NH:14][CH2:9][CH2:8][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:13]

Participants

4

Reactant 3

HCID 6212ChloroformHCID 6363IsopropylamineHCID 68526Benzene, (2-bromoethoxy)-

Product 1

HCID 47000767HCID 47000767, compound

Procedure

Following the procedure of Preparation 1, 2-bromoethyl phenyl ether and isopropyl amine were reacted (in refluxing chloroform) overnight and the reaction mixture processed to yield an oil, the free base of the title compound. A portion of the oil was reacted with ethereal hydrogen chloride to form the hydrochloride salt in 68.3% yield, m.p. 152°-154.5° C.

Workup

  1. customwere reacted
  2. customto yield an oil

Sources & evidence

ORD record
ord-b99d475fc2424657bad3009b4cf86e4e
Source dataset
uspto-grants-1985_12
Patent number
US04558155

Reaction notes

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