Isopropylamine → HCID 86051534, compound

HRID 637837Notes

Reaction equation

HRID 637837 reaction equation
BrCCC1C([Cl:10])=CC=[CH:6][C:5]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=1CCBr.[CH:22]([NH2:25])([CH3:24])[CH3:23]>>[ClH:10].[Cl:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][CH2:5][CH2:6][NH:25][CH:22]([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 131714114HCID 131714114, compound

Product 1

HCID 86051534HCID 86051534, compound

Procedure

Following the procedure of Preparation 11, 2-bromoethyl-3-chlorophenyl ether and isopropyl amine in excess were reacted and the reaction mixture processed to yield an oil, the free base of the title compound. A portion of the oil converted to the hydrochloride salt (77.8%), m.p. 153.5°-155.5° C.

Workup

  1. customin excess were reacted
  2. customto yield an oil

Sources & evidence

ORD record
ord-0bee33e581b54e6091a26f79ce2d0537
Source dataset
uspto-grants-1985_12
Patent number
US04558155

Reaction notes

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