Water → HCID 20256351, compound

HRID 637855Notes

Reaction equation

HRID 637855 reaction equation
C(O)(=O)/C=C\C(O)=[O:5].[Cl:9][C:10]1[CH:11]=[C:12]([CH:28]=[C:29]([Cl:31])[CH:30]=1)[O:13][CH2:14][CH2:15][N:16]([CH:25]([CH3:27])[CH3:26])[C:17]([NH:19][CH2:20][CH2:21][N:22]([CH3:24])[CH3:23])=[O:18].[OH-].[Na+].O>>[OH2:5].[Cl:9][C:10]1[CH:11]=[C:12]([CH:28]=[C:29]([Cl:31])[CH:30]=1)[O:13][CH2:14][CH2:15][N:16]([CH:25]([CH3:27])[CH3:26])[C:17]([NH:19][CH2:20][CH2:21][N:22]([CH3:23])[CH3:24])=[O:18]

Participants

4

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 70472636HCID 70472636, compound

Product 1

HCID 20256351HCID 20256351, compound

Procedure

A solution of N-[2-(3,5-dichlorophenoxy)ethyl]-N'-[2-(dimethylamino)ethyl]-N-(1-methylethyl)urea Maleate [1:1], from Example 3A, was basified with 2M sodium hydroxide solution and extracted with methylene chloride. The methylene chloride layer was dried over magnesium sulfate and evaporated under vacuum to give an oil. Nuclear magnetic resonance measurements showed the product had 1/2 equivalent of water present.

Workup

  1. extractionextracted with methylene chloride
  2. dry with materialThe methylene chloride layer was dried over magnesium sulfate
  3. customevaporated under vacuum
  4. customto give an oil

Sources & evidence

ORD record
ord-38ee93be548d44e2a3a1a241b86d30ab
Source dataset
uspto-grants-1985_12
Patent number
US04558155

Reaction notes

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