HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzaldehyde → Methyl 2-p-nitrophenyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-formate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzaldehyde | HCID 541 | — |
| Reactant | Methyl 1-amino-5-carbamoyl-1H-pyrrole-3-carboxylate | HCID 66985220 | — |
| Product | Methyl 2-p-nitrophenyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-formate | HCID 136843825 | 72% |
Reaction Steps
According to the general preparation method described in example 5 above, p-nitrobenzaldehyde reacts with compound 3 to give compound Ma as light yellow solid in 72.0% yield. m.p.>300° C. 1H NMR (300 MHz, DMSO-d6): δ 12.52 (s, 1H), 8.38 (d, J=8.5 Hz, 2H), 8.22 (s, 1H), 8.21 (d, J=8.5 Hz, 2H), 7.26 (s, 1H), 3.80 (s, 3H). LRMS (EI) m/z (%): 314 (M+, 85), 283 (100). HRMS calcd. C14H10N4O5: 314.0651. found: 314.0659.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447101B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-7244964fa05d4bb09bff1097c61c2a67 |
| Source note | uspto-grants-2016_09 |