反应详情

4.12 g of 1-(2-biphenylsulfonyl)3-(4,6-dimethylpyrimidin-2-yl)2-methylisothiourea was dissolved in 50 ml of dioxane, 2.35 g of O-methylhydroxylamine was added to the solution, and the mixture was heated under reflux for 5 hours. After cooling the reaction mixture, the solvent was evaporated under reduced pressure. The residue was recrystallized from ethanol to give 2.6 g of the desired N-(2-biphenylsulfonyl)N'-(4,6-dimethylpyrimidin-2-yl)N"-(methoxy)guanidine of the following formula, mp. 190°-192° C.: ##STR21##

1. temperaturethe mixture was heated
2. temperatureunder reflux for 5 hours
3. temperatureAfter cooling the reaction mixture
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was recrystallized from ethanol