Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Bromobenzenesulfonamide | HCID 2801263 | — |
| Reactant | HCID 178454796 | HCID 178454796 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54062463 | HCID 54062463 | — |
Reaction Steps
A solution of 11.8 g (0.05 mole) of 2-bromophenylsulfonamide in 14 ml (0.1 mole) of triethylamine and 3 ml of dimethylformamide is treated with 6.8 g (0.05 mole) of isobutyl methylphosphinate and 1.1 g (0.001 mole) of tetrakistriphenylphosphine-palladium complex. The yellow suspension is stirred for 15 hours at 100° C., cooled and filtered. After the filtrate has been evaporated, the residue is crystallised from toluene. This gives 4.12 g of 2-(i-butoxy-P-methylphosphinyl)-phenylsulfonamide, melting point 50°-52° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04559078 |
|---|
| Source dataset | uspto-grants-1985_12 |
|---|
| ORD ID | ord-718ab7c963ab4ca882161dd63c5062ae |
|---|
| Source note | uspto-grants-1985_12 |
|---|
