反应详情

Combine the product of step A (12.2 g) with sodium azide (3.9 g) in DMF (200 ml). Stir 44 hours, extract with ethyl acetate, wash with water, dry the organic layer over MgSO4 and concentrate. Dissolve the resultant residue in ethanol (150 ml), add 5.0 g 10Pd/C and hydrogenate at 3 atm for 4 hours. Filter and concentrate the filtrate to obtain 2-(2-aminoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine.

1. extractionextract with ethyl acetate
2. washwash with water
3. dry with materialdry the organic layer over MgSO4
4. concentrationconcentrate
5. dissolutionDissolve the resultant residue in ethanol (150 ml)
6. additionadd 5.0 g 10Pd/C
7. waithydrogenate at 3 atm for 4 hours
8. filtrationFilter
9. concentrationconcentrate the filtrate