HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → Ciprofloxacin EP IMpurity B
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 7-Chloro-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13385163 | — |
| Product | Ciprofloxacin EP IMpurity B | HCID 483178 | — |
Reaction Steps
Analogously to Example C, 7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid is reacted with piperazine to give 1-cyclopropyl-1,4-dihydro-4-oxo-7-(piperazin-1-yl)-quinoline-3-carboxylic acid which decomposes at 298°-300° C. Preparation Examples for the end products according to the invention:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04559341 |
| Source dataset | uspto-grants-1985_12 |
| ORD ID | ord-68faa4a807ed4abfb137b04a5ea04142 |
| Source note | uspto-grants-1985_12 |