HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 637930Generated: October 26, 2026
Sodium Hydroxide → 4,6-Dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine
https://huagongshe.com/reaction/637930
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | Thiobarbituric acid | HCID 2723628 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4,6-Dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine | HCID 178491709 | 54.5% |
Reaction Steps
To a suspension of thiobarbituric acid (15 g) in 50% ethanol (180 ml) are added a solution of NaOH (5.1 g) in 50% ethanol (75 ml) and p-methoxybenzyl chloride (18.7 g). The mixture is heated under stirring for 60' at 60° C.; then it is cooled and the solid is filtered by suction, washed with water; then dried over CaCl2, yielding 15 g of 2-p-methoxy-benzylthio-4,6-dihydroxypyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04559345 |
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| Source dataset | uspto-grants-1985_12 |
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| ORD ID | ord-5d6de63010204f47b9d61cc676dd9f97 |
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| Source note | uspto-grants-1985_12 |
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