反应详情

To a solution of 2-p-methoxybenzylthio-4,6-dichloro-pyrimidine (19.8 g) in acetonitrile (100 l) is added 2,3-xylidine (16 ml) and the resulting mixture is refluxed for 36 hours. The solid is filtered, washed with a little amount of acetonitrile, then the filtrate is concentrated to dryness. The residue is purified by chromatography on silica-gel. 17 g of the desired product are obtained. M.p. 118°-119° C. (benzene/hexane).

1. temperaturethe resulting mixture is refluxed for 36 hours
2. filtrationThe solid is filtered
3. washwashed with a little amount of acetonitrile
4. concentrationthe filtrate is concentrated to dryness
5. customThe residue is purified by chromatography on silica-gel