反应详情

To the suspension of N-[4-chloro-6-(2,3-xylidino)-2-pyrimidinyl]-aminoacetic acid ethyl ester (2.23 g; examples 3a and 5) in ethanol (27 ml) at 60° C., 1N NaOH (13.5 ml) is added, and the mixture is heated for 5'; then diluted with water, evporated under vacuum and extracted with diethyl ether (2×20 ml). After acidification with glacial acetic acid, the precipitate is filtered and washed with water to neutrality. The solid is then dried under vacuum with CaCT2, and 1.9 g of the desired acid are obtained (I, 1). With the same method the following compounds have been prepared:

1. temperaturethe mixture is heated for 5'
2. extractionextracted with diethyl ether (2×20 ml)
3. filtrationAfter acidification with glacial acetic acid, the precipitate is filtered
4. washwashed with water to neutrality
5. dry with materialThe solid is then dried under vacuum with CaCT2, and 1.9 g of the desired acid
6. customare obtained (I, 1)
7. customWith the same method the following compounds have been prepared