2,3-Dimethylaniline → 6-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

Participants

Reaction Steps

To a solution of 2-octylthio-4,6-dichloropyrimidine (3 g) in ethanol (25 ml), 2,3-xylidine (1,5 ml) and anhydrous Na2CO3 (1.25 g) are added; the mixture is refluxed for 20 hours. The residue is hot filtered and the solvent is evaporated. The residue is purified by chromathography on silica gel, yielding 1.9 g of 2-octylthio-4-chloro-6-(2,3-xylidino)-pyrimidine (III, 35).

Provenance & Evidence