4-(Dimethylcarbamoyl)benzoic acid → HCID 72548866, compound

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Reaction Steps

According to the general method described in example 13, 4-(dimethylcarbamoyl)benzoic acid was used as starting material, and the resulting 4-(dimethylcarbamoyl)benzoyl azide reacted with 13a to give a light yellow solid (14 mg, 25.8%). m.p. 240° C. 1H NMR (300 MHz, DMSO-d6): δ 9.59 (s, 2H), 8.16 (d, J=8.5 Hz, 2H), 7.99 (s, 1H), 7.58 (d, J=8.5 Hz, 2H), 7.52 (d, J=8.5 Hz, 2H), 7.36 (d, J=8.5 Hz, 2H), 7.19 (s, 1H), 4.25 (s, 2H), 4.08 (t, J=4.4 Hz, 4H), 3.80 (t, J=4.4 Hz, 4H), 2.96 (s, 6H), 2.69 (s, 6H). ESI-MS: 543 (4+1).

Provenance & Evidence