4-(4-methylpiperazine-1-carbonyl)benzoic Acid → 1-(4-(6-((Dimethylamino)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea

Participants

Reaction Steps

According to the general methods described in example 13, 4-(4-methylpiperazine-1-carbonyl)benzoic acid was used as starting material, and the resulting 4-(4-methylpiperazine-1-carbonyl)benzoyl azide reacted with 13a to give a white solid (9 mg, 15.1%). 1H NMR (300 MHz, DMSO-d6): δ 9.63 (br, s, 2H), 8.16 (d, J=8.9 Hz, 2H), 7.92 (s, 1H), 7.57 (d, J=8.9 Hz, 2H), 7.53 (d, J=8.5 Hz, 2H), 7.34 (d, J=8.5 Hz, 2H), 7.13 (s, 1H), 4.07 (br, s, 6H), 3.80 (br, s, 4H), 3.51 (br, s, 4H), 3.06 (br s, 2H), 2.55 (s, 6H), 2.38 (br s, 2H), 2.24 (s, 3H). ESI-MS: 598 (M+1).

Provenance & Evidence