Water → HCID 20254771, compound

Participants

Reaction Steps

537 mg (1.5 mmol) of 1-cyclopropyl-1,4-dihydro-6-nitro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid are heated under reflux in a mixture of 7.5 ml of glycol monomethyl ether and 3 ml of dimethylsulphoxide with 2 g of methyl acrylate for 8 hours. 10 ml of water are added to the solution and the precipitate is filtered off with suction, washed with methanol and dried. 0.5 g of 1-cyclopropyl-1,4-dihydro-7-[4-(2-ethoxycarbonylethyl)-1-piperazinyl]-6-nitro-4-oxo-3-quinolinecarboxylic acid of decomposition point 208° to 211° C. is obtained.

Provenance & Evidence