HCID 117988523, compound → 2-(3-(hydroxymethyl)phenyl)-N,N-dimethyl-4-morpholinopyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

HRID 63796Notes

Reaction equation

HRID 63796 reaction equation
N[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[C:11]3=[CH:20][C:21]([C:23]([N:25]([CH3:27])[CH3:26])=[O:24])=[CH:22][N:10]3[N:9]=2)=[CH:4][CH:3]=1.[OH:28][CH2:29]C1C=C(C2N=C(N3CCOCC3)C3=CC(C(O)=O)=CN3N=2)C=CC=1>>[OH:28][CH2:29][C:7]1[CH:6]=[C:5]([C:8]2[N:13]=[C:12]([N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[C:11]3=[CH:20][C:21]([C:23]([N:25]([CH3:26])[CH3:27])=[O:24])=[CH:22][N:10]3[N:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 117988523HCID 117988523, compoundHCID 117997988HCID 117997988, compound

Product 1

HCID 1179878762-(3-(hydroxymethyl)phenyl)-N,N-dimethyl-4-morpholinopyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

Procedure

Compound 18 was prepared by the method which was identical with that for preparing compound 12a, wherein compound 17 (92 mg, 0.26 mmol) was used as the starting material. White solid (80 mg, 80.8%). m.p. 170-171° C. 1H NMR (300 MHz, CDCl3): δ 8.22 (s, 1H), 8.20-8.17 (m, 1H), 7.84 (d, J=1.5 Hz, 1H), 7.46-7.43 (m, 2H), 7.04 (d, J=1.5 Hz, 1H), 4.77 (s, 2H), 4.11 (t, J=4.7 Hz, 4H), 3.87 (t, J=4.7 Hz, 4H), 3.20 (br, s, 6H). LC-MS: 382 (M+1).

Sources & evidence

ORD record
ord-f43727d52c14457d84ba7dfbeaf4afc7
Source dataset
uspto-grants-2016_09
Patent number
US09447101B2

Reaction notes

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