反应详情

7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (0.5 g, 0.003 mole) was heated at reflux temperature under nitrogen in p-phenetidine for 8 h. The mixture was left to stand at room temperature while a blue/black precipitate formed. This was collected, washed with water and ethyl acetate and the residue, a grey solid, was recrystallized from ethanol with charcoal present to give the required product as an off-white solid (0.11 g, 14%), m.p. 217° C.

1. waitThe mixture was left
2. customto stand at room temperature while a blue/black precipitate
3. customformed
4. customThis was collected
5. washwashed with water and ethyl acetate
6. customthe residue, a grey solid, was recrystallized from ethanol with charcoal present