Acetone → HCID 20254912, compound

Participants

Reaction Steps

0.38 g (0.01 mol) of sodium borohydride are added, while stirring, to a suspension of 4.1 g (0.01 mol) of 5-cyano-N-[2-[4-(p-fluorobenzoyl)-piperidinyl]ethyl]-2-methoxybenzamide in 50 ml of ethanol and the whole is stirred for 1 hour at room temperature. There is added to the resulting clear solution 1 ml of acetone and the whole is then concentrated in a water-jet vacuum. The residue is taken up in methylene chloride and water, the layers are separated in a separating funnel and, after being dried over magnesium sulphate, the organic phase is concentrated by evaporation. 5-Cyano-N-[2-[4-[(4-fluorophenyl)hydroxymethylene]-piperidinyl]-ethyl]-2-methoxybenzamide of melting point 135°-137° is obtained as residue.

Provenance & Evidence