HCID 13067575, compound → HCID 13067590, compound

Participants

Reaction Steps

In 50 ml of methanol was dissolved 1 g of trans-2-benzyloxy-5-hydroxy-6-(1-methyl-3-phenylpropylamino)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide hydrochloride and catalytic reduction was carried out in the presence of 1 g of 10% palladium-on-carbon at atmospheric temperature and pressure. After the absorption of hydrogen was completed, the catalyst was filtered off and the filtrate was distilled under reduced pressure. To the residue was added 50 ml of ethyl ether, whereby 0.56 g of trans-2,5-dihydroxy-6-(1-methyl-3-phenylpropylamino)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide hydrochloride was obtained as colorless powder.

Provenance & Evidence