HCID 13388141, compound → KC 764

HRID 638009Notes

Reaction equation

HRID 638009 reaction equation
[CH3:1][C:2]1[C:10]([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[N:14][CH:13]=2)=[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[H][H]>C(O)C.[C].[Pd]>[CH3:1][C:2]1[C:10]([C:11](=[O:18])[C:12]2[CH2:17][CH2:16][CH2:15][NH:14][CH:13]=2)=[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1

Participants

5

Reactant 2

HCID 13388141HCID 13388141, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 146826KC 764

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Ten g of 2-methyl-3-nicotinoyl pyrazolo[1,5-a]pyridine was dissolved in 150 ml of absolute ethanol and 2 g of 10% palladium carbon was added to the solution. The mixture was hydrogenated in an autoclave at 13 atm. of hydrogen at a temperature in the range of 55° to 58° C. for 3 hours. The mixture was filtered and the filtrate was evaporated under reduced pressure in order to remove the solvent. The residue was recrystallized from ethyl acetate to afford the title compound in yield of 8.5 g, mp 207°-208° C.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated under reduced pressure in order
  3. customto remove the solvent
  4. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-5d8231c11538411dafdae996d4804571
Source dataset
uspto-grants-1985_12
Patent number
US04559402

Reaction notes

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