4-Chlorophenyl Isocyanate → HCID 13388142, compound

HRID 638010Notes

Reaction equation

HRID 638010 reaction equation
[CH3:1][C:2]1[C:10]([C:11](=[O:18])[C:12]2[CH2:17][CH2:16][CH2:15][NH:14][CH:13]=2)=[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[O:28])=[CH:22][CH:21]=1>C(Cl)Cl>[CH3:1][C:2]1[C:10]([C:11](=[O:18])[C:12]2[CH2:17][CH2:16][CH2:15][N:14]([C:27](=[O:28])[NH:26][C:23]3[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=3)[CH:13]=2)=[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1

Participants

4

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 146826KC 764

Product 1

HCID 13388142HCID 13388142, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

One g of 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)-pyrazolo[1,5-a]pyridine was dissolved in 20 ml of methylene chloride and 1 g of p-chlorophenyl isocyanate was added dropwise whilst stirring to the solution. The mixture was stirred at room temperature for 2 hours, and after removal of solvent in vacuo, the residue was recrystallized from ethyl acetate to afford the title compound in yield of 1.2 g (73%), mp 198°-200° C.

Workup

  1. stirringThe mixture was stirred at room temperature for 2 hours
  2. customafter removal of solvent in vacuo
  3. customthe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-3d075a8de80d4035a1a9599cad3a08b7
Source dataset
uspto-grants-1985_12
Patent number
US04559402

Reaction notes

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