HCID 117988125, compound → 2-(6-Amino-4-(trifluoromethyl)pyridin-3-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

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Reaction Steps

Compound 23b was prepared by the method which was identical with that for preparing compound 23a, wherein compound 22b (250 mg, 0.45 mmol) was used as the starting material. White solid (102 mg, 51.9%). m.p. 284-285° C. 1H NMR (300 MHz, DMSO-d6): δ 12.44 (br s, 1H), 8.36 (s, 1H), 8.11 (s, 1H), 7.30 (s, 1H), 6.82 (s, 3H), 4.47 (br s, 2H), 4.42 (br s, 2H), 3.32 (br s, 2H), 1.87-1.84 (m, 2H), 1.75-1.68 (m, 2H). LC-MS: 435 (M+1).

Provenance & Evidence