5-[2-(Benzylamino)-ethoxy]-salicylamide → 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-[1-methyl-4-(trifluoromethyl)-imidazol-2-yl]-phenoxy]-2-propanol

Participants

Reaction Steps

A solution of 5 g of 2-[4-(2,3-epoxypropoxy)-phenyl]-1-methyl-4-(trifluoromethyl)-imidazole and 4.7 g of 5-[2-(benzylamino)-ethoxy]-salicylamide in 100 ml of isopropanol is heated under reflux for 15 hours and the solvent is subsequently removed in a rotary evaporator. The crude 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-[1-methyl-4-(trifluoromethyl)-imidazol-2-yl]-phenoxy]-2-propanol, obtained in the form of an oil, is further processed in that form.

Provenance & Evidence