Ammonia → HCID 136387283, compound

Participants

Reaction Steps

A solution of 19.6 g of 2-[1-benzyl-4-(trifluoromethyl)-imidazol-2-yl]-5-(4-methoxyphenyl)-furan and 8.1 g of D,L-methionine in 110 ml of methanesulphonic acid is stirred under nitrogen for 20 hours at 100°. After cooling, the reaction mixture is poured onto ice, the pH is adjusted to 8 with concentrated ammonia and the mixture is extracted several times with methylene chloride. Washing with water, drying and concentration by evaporation of the organic phase yield the crystalline 2-[1-benzyl-4-(trifluoromethyl)-1H-imidazol-2-yl]-5-(4-hydroxyphenyl)-furan which is used as such in the next step.

Provenance & Evidence