HCID 20255153, compound → HCID 20255146, compound

Participants

Reaction Steps

A solution of 13.2 g of crude 1-[N-benzyl-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]]-3-[4-(4-acetyl-1,5-dimethyl-1H-imidazol-2-yl)-phenoxy]-2-propanol in 140 ml of methanol is hydrogenated with the addition of 1.3 g of palladium-on-carbon catalyst until 1 molar equivalent of hydrogen has been absorbed. After filtration and evaporation of the solvent, an oil is obtained which, after recrystallising twice from ethanol, yields 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(4-acetyl-1,5-dimethyl-1H-imidazol-2-yl)-phenoxy]-2-propanol having a melting point of 128°-130°.

Provenance & Evidence