Epichlorohydrin → HCID 20255056, compound

Participants

Reaction Steps

The mixture of 17.0 g of 2-(4-hydroxyphenyl)-4-methyl-6-(trifluoromethyl)-pyrimidine, 23.1 g of potassium carbonate and 135 ml of epichlorohydrin is stirred at a temperature of 130° for 1.5 hours, then filtered with suction while hot; the filter residue is subsequently washed with methylene chloride and the filtrate is evaporated to dryness under reduced pressure. The residue is recrystallised from isopropanol and yields 2-[4-(2,3-epoxypropoxy)-phenyl]-4-methyl-6-(trifluoromethyl)pyrimidine having a melting point of 97°-99°.

Provenance & Evidence