Water → Fumarate

Participants

Reaction Steps

11.6 g of 1-[N-benzyl-2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(3,5-dicarboethoxy-2,6-dimethylpyridin-4-yl)-phenoxy]-2-propanol are hydrogenated and worked up analogously to Example 1. The resulting base is reacted with fumaric acid in isopropanol and the resulting salt is recrystallised from ethanol. After drying for 15 hours at 0.05 mm Hg and 80°, 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(3,5-dicarboethoxy-2,6-dimethylpyridin-4-yl)-phenoxy]-2-propanol is obtained in the form of a neutral fumarate with 1/4 mole of water of crystallisation and has a melting point of 133°-135°.

Provenance & Evidence