Epichlorohydrin → HCID 54334007, compound

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Reaction Steps

9.0 g of the resulting 2,6-dimethyl-4-(4-hydroxyphenyl)-pyridine-3,5-dicarboxylic acid diethyl ester are dissolved in a solution prepared from 0.723 g of sodium metal and 80 ml of ethanol. This solution is slowly added drop-wise to a boiling solution of 11.9 ml of epichlorohydrin in 80 ml of ethanol; after cooling, the sodium chloride that is deposited is filtered off with suction and the filtrate is concentrated to dryness by evaporation. The residue is dissolved in ether and washed in succession with aqueous 1N sodium hydroxide solution, 1N hydrochloric acid, saturated aqueous potassium bicarbonate solution and finally with water. After distilling off the ether, the crude 2,6-dimethyl-4-[4-(2,3-epoxypropoxy)-phenyl]-pyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of a yellow oil.

Provenance & Evidence