5-[2-(Benzylamino)-ethoxy]-salicylamide → 1-[N-benzyl-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]]-3-[2-(indol-2-yl)-phenoxy]-2-propanol

Participants

Reaction Steps

The starting compound is obtained in the following manner: (13a) A solution of 10.5 g of 2-[2-(2,3-epoxypropoxy)-phenyl]-indole and 10.2 g of 5-(2-benzylaminoethoxy)-salicylamide in 300 ml of isopropanol is reacted analogously to Example 4(c) and yields crude 1-[N-benzyl-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]]-3-[2-(indol-2-yl)-phenoxy]-2-propanol in the form of an orange resin that is further processed in that form.

Provenance & Evidence