HCID 20255099, compound → HCID 20255197, compound

Participants

Reaction Steps

With the addition of 3.0 g of palladium-on-carbon catalyst (10%), a solution of 16 g of crude 1-[N-benzyl-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]]-3-[4-(4-methyl-5-trifluoromethyl-4H-1,2,4-triazol-3-yl)-phenoxy]-2-propanol in 160 ml of methanol is catalytically hydrogenated under normal conditions until, after 35 hours, the calculated quantity of hydrogen has been absorbed (an additional quantity of 2 g of catalyst is required for this purpose). Filtration and concentration by evaporation of the filtrate produce a semi-solid mass which, by recrystallisation from isopropanol using active carbon, yields 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(4-methyl-5-trifluoromethyl-4H-1,2,4-triazol-3-yl)-phenoxy]-2-propanol having a melting point of 151°-153°.

Provenance & Evidence