Methanol → Cgp-20712

HRID 638046Notes

Reaction equation

HRID 638046 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][C:5]1[CH:13]=[C:9]([C:10]([NH2:12])=[O:11])[C:8]([OH:14])=[CH:7][CH:6]=1.[O:15]1[CH2:35][CH:16]1[CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[N:26]([CH3:34])[CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[N:29]=2)=[CH:21][CH:20]=1.CO>CS(C)=O>[C:10]([C:9]1[CH:13]=[C:5]([CH:6]=[CH:7][C:8]=1[OH:14])[O:4][CH2:3][CH2:2][NH:1][CH2:35][CH:16]([OH:15])[CH2:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[N:26]([CH3:34])[CH:27]=[C:28]([C:30]([F:32])([F:33])[F:31])[N:29]=2)=[CH:23][CH:24]=1)(=[O:11])[NH2:12]

Participants

5

Reactant 3

HCID 887MethanolHCID 202550772-[4-(2,3-Epoxypropoxy)-phenyl]-1-methyl-4-(trifluoromethyl)-imidazoleHCID 230496945-(2-Aminoethoxy)-2-hydroxybenzamide

Product 1

HCID 2685Cgp-20712

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A solution of 3.9 g of 5-(2-aminoethoxy)-salicylamide in 30 ml of dimethyl sulphoxide is heated to 70° and 7.2 g of 2-[4-(2,3-epoxypropoxy)-phenyl]-1-methyl-4-(trifluoromethyl)-1H-imidazole are added. The reaction mixture is stirred for 1 hour at 70° and worked up analogously to Example 12. 1-[2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)-phenoxy]-2-propanol having a melting point of 195°-197° is obtained (from methanol).

Sources & evidence

ORD record
ord-af19be546d3d4276aa539d3791f751e1
Source dataset
uspto-grants-1985_12
Patent number
US04559354

Reaction notes

Loading…