Ammonia → HCID 136018549, compound

Participants

Reaction Steps

A solution of 14.6 g of 1-(2-hydroxyethyl)-2-(4-methoxyphenyl)-4-(trifluoromethyl)-1H-imidazole and 8.7 g of DL-methionine in 90 ml of methanesulphonic acid is stirred for 24 hours at 110°, then cooled, poured onto ice and the pH is adjusted to 10 with ammonia. The mixture is extracted several times with ethyl acetate, the combined organic phases are dried over sodium sulphate, filtered and the filtrate is concentrated to a small volume. 1-(2-hydroxyethyl)-2-(4-hydroxyphenyl)-4-(trifluoromethyl)-1H-imidazole having a melting point of 186°-188° can be obtained in crystalline form by the addition of hexane.

Provenance & Evidence